DJ-1 can form β-sheet structured aggregates that co-localize with pathological amyloid deposits
نویسندگان
چکیده
منابع مشابه
Amyloid β-Sheet Mimics that Antagonize Amyloid Aggregation and Reduce Amyloid Toxicity
The amyloid protein aggregation associated with diseases such as Alzheimer's, Parkinson's and type II diabetes (among many others) features a bewildering variety of β-sheet-rich structures in transition from native proteins to ordered oligomers and fibres. The variation in the amino-acid sequences of the β-structures presents a challenge to developing a model system of β-sheets for the study of...
متن کاملDecontamination of medical devices from pathological amyloid-β-, tau- and α-synuclein aggregates
Prion-like features and possible hazards of amyloid-β-, tauand α-synuclein aggregates Increasing evidence suggests that the misfolding and aggregation of different disease-associated proteins such as amyloid-β (Aβ) and tau in Alzheimer’s disease (AD), α-synuclein in Parkinson’s Disease (PD) and dementia with Lewy bodies (DLB), or prion protein (PrP) in prion diseases is based on a common molecu...
متن کاملAmide solvent protection analysis demonstrates that amyloid-β(1–40) and amyloid-β(1–42) form different fibrillar structures under identical conditions
AD (Alzheimer’s disease) is a neurodegenerative disorder characterized by self-assembly and amyloid formation of the 39–43 residue long Aβ (amyloid-β)-peptide. The most abundant species, Aβ(1–40) and Aβ(1–42), are both present within senile plaques, but Aβ(1–42) peptides are considerably more prone to selfaggregation and are also essential for the development of AD. To understand the molecular ...
متن کاملMediator tail subunits can form amyloid-like aggregates in vivo and affect stress response in yeast
The Med2, Med3 and Med15 proteins form a heterotrimeric subdomain in the budding yeast Mediator complex. This Med15 module is an important target for many gene specific transcription activators. A previous proteome wide screen in yeast identified Med3 as a protein with priogenic potential. In the present work, we have extended this observation and demonstrate that both Med3 and Med15 form amylo...
متن کاملMR microscopy of human amyloid-β deposits: characterization of parenchymal amyloid, diffuse plaques, and vascular amyloid.
Cerebral deposits of amyloid-β peptides (Aβ) form the neuropathological hallmarks of Alzheimer's disease (AD) and cerebral amyloid angiopathy (CAA). In the brain, Aβ can aggregate as insoluble fibrils present in amyloid plaques and vascular amyloid, or as diffuse plaques consisting of mainly non-fibrillar Aβ. Previously, magnetic resonance imaging (MRI) has been shown to be capable of detecting...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Neurobiology of Disease
سال: 2020
ISSN: 0969-9961
DOI: 10.1016/j.nbd.2019.104629